At the turn of the last century, the emerging field of medical oncology chose a cytotoxic
approach to cancer therapy over an immune-centered approach at a time when evidence in …

It is well established that natural killer (NK) cells are involved in both innate and adaptive
immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals …

The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural
variation and high sequence similarity among genes, imposing technical difficulties for …

Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary
approach. In this context, integrating knowledge of immune function with an understanding …

The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …

Background To analyze the correlation between the inducing effect of Fusobacterium
nucleatum (Fn) on the surface expression of the inhibitory receptor KIR2DL1 on CD8+ T …

Cancer immunotherapies are preferred over conventional treatments which are highly
cytotoxic to normal cells. Focus has been on T cells but natural killer (NK) cells have equal …

The killer-cell immunoglobulin-like receptor (KIR) region comprises a fast-evolving family of
genes that encode receptors for natural killer (NK) cells and have crucial role in host …

Interactions of human natural killer (NK) cell inhibitory receptors with polymorphic HLA-A,-B
and-C molecules educate NK cells for immune surveillance against tumor cells. The KIR A …

Certain Killer Immunoglobulin-Like Receptor (KIR)/KIR HLA Class I Ligand Genotypes Influence
Natural Killer Antitumor Activity i Page 1 Objective: Natural killers (NK) cell function is mainly …