The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

Notch signaling plays many important roles in homeostasis and remodeling in the vessel
wall, and serves a critical role in the communication between endothelial cells and smooth …

Histone methyl transferase EZH2 (Enhancer of Zeste Homolog 2) is generally associated
with H3K27 methylation and gene silencing, as a member of the polycomb repressor 2 …

Repurposing of approved non-antitumor drugs represents a promising and affordable
strategy that may help to increase the repertoire of effective anticancer drugs. Benzimidazole …

Objective To define the role of wait-and-scan and radiotherapy (RT) in the treatment of
temporal bone paragangliomas and to review the literature on the outcomes of RT as a …

Paragangliomas (PGLs) are infiltrating autonomic nervous system tumors that cause
important morbidity. At present, surgery is the only effective therapeutic option for this rare …

Background Genome-wide association studies have identified more than 60 single
nucleotide polymorphisms associated with Body Mass Index (BMI). Additional genetic …

Simple Summary Neuroendocrine neoplasia comprise many distinct and rare subtypes of
cancers. Preclinical models are essential for improving understanding of these diseases …

SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA
viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that …

Head and neck paragangliomas (HNPGLs) are rare tumors that may cause important
morbidity, because of their tendency to infiltrate the skull base. At present, surgery is the only …