High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

New Findings What is the central question of this study? Herein, a methodological overview
of our research team's (Global REACH) latest high altitude research expedition to Peru is …

Key points We sought to determine the isolated and combined influence of hypovolaemia
and hypoxic pulmonary vasoconstriction on the decrease in left ventricular (LV) function and …

Rationale: Chronic exposure to hypoxia is associated with elevated sympathetic nervous
activity and reduced vascular function in lowlanders, and Andean highlanders suffering from …

Background and aims Exposing the endothelium to acute periods of imposed oscillatory
shear stress reduces endothelial function and elevates circulating microparticles (MPs) …

Exposure to hypoxia elicits widespread physiological responses that are critical for
successful acclimatization; however, these responses may induce apparent maladaptive …

High-altitude exposure typically reduces endothelial function, and this is modulated by
hemoconcentration resulting from plasma volume contraction. However, the specific impact …

The first ascent of Mount Everest by Tenzing Norgay and Sir Edmund Hillary in 1953 brought
global attention to the Sherpa people and human performance at altitude. The Sherpa …

Intermittent (IH), as opposed to continuous hypoxia (CH), is thought to have beneficial effects
on cardiovascular function and health. In the present study, we examined the acute effects of …