Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

DNA/cationic lipid (lipoplexes), DNA/cationic polymer (polyplexes) and DNA/cationic
polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non‐viral …

Gene therapy offers great opportunities for the treatment of severe diseases including
cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become …

Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far
less effective for the applications with siRNA. In the current study, we generated a number of …

Synthetic small interfering RNA (siRNA) presents an exciting novel medical opportunity.
Although researchers agree that siRNA could have a great therapeutic impact, the required …

During the past decade, RGD-peptides have become a popular tool for the targeting of
drugs and imaging agents to αvβ3-integrin expressing tumour vasculature. RGD-peptides …

Abstract siRNA is considered as a potent therapeutic agent because of its high specificity
and efficiency in suppressing genes that are overexpressed during disease development …

RNA interference (RNAi) is one of the most importantly protective phenomena forming from
the process combating against virus. Since its high efficiency for silencing the expression of …

The promise of nucleic acid based oligonucleotides as effective genetic therapies has been
held back by their low bioavailability and poor cellular uptake to target tissues upon systemic …