DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …

Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

Breast cancer is one of the major health issues confronting women; however, treatment with
conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a …

Aim Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in a
background of chronic liver disease and prolonged inflammation. A major contributor in the …

Background Treatment options for hepatocellular carcinoma (HCC) are limited, and overall
survival is poor. Despite the high frequency of this malignoma, its basic disease …

PARP-1 inhibition has recently been employed in both mono-and combination therapies in
various malignancies including melanoma with both promising and contradicting results …

Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with
the development of certain cancers; however, no studies have specifically examined the role …

Background A promising avenue for cancer treatment is exacerbating the deregulation of the
DNA repair machinery that would normally protect the genome. To address the applicability …

Hepatocellular carcinoma (HCC) is a major global health concern, representing one of the
leading causes of cancer-related deaths. Despite various treatment options, the prognosis …

Hepatocellular carcinoma (HCC) is the leading cause of cancer death worldwide that lacks
proper medical prognosis and treatment. In the present study, the anti-tumoral potential of …