The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current
therapies are not curative, and patients' outcomes remain poor with an overall survival of …

Xp11. 2 translocation renal cell carcinoma (Xp11 tRCC) is a rare sporadic pediatric kidney
cancer caused by constitutively active TFE 3 fusion proteins. Tumors in patients with Xp11 …

Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic
dysregulation has been associated with the initiation and progression of pancreatic tumors …

Purpose Peritumoural brain zone (PT) of glioblastoma (GBM) is the area where tumour
recurrence is often observed. We aimed to identify differentially regulated genes between …

Rationale: Tumors have significant abnormalities in various biological properties. In renal
cell carcinoma (RCC), metabolic abnormalities are characteristic biological dysfunction that …

Peptides/small proteins, encoded by noncanonical open reading frames (ORF) of previously
claimed non-coding RNAs, have recently been recognized possessing important biological …

Interferon (IFN) regulatory factor 8 is encoded by a novel candidate tumor suppressor gene
(IRF8), its promotor is frequently methylated in multiple cancers. However, the promoter …

The enhancer of zeste homolog 2 (EZH2) is a core subunit of the polycomb repressor
complex 2 (PRC2), which is overexpressed in numerous cancers and mutated in several …

Cyclin D2 (CCND2) is a member of the D-type cyclins, which plays a pivotal role in cell cycle
regulation, differentiation and malignant transformation. However, its expression status and …