Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that currently has no
cure, but treatments are available to improve PD symptoms and maintain quality of life. In …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Parkinson's disease (PD) is a serious neurodegenerative disorder marked by significant
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …

Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …

Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …

Despite decades of research, current therapeutic interventions for Parkinson's disease (PD)
are insufficient as they fail to modify disease progression by ameliorating the underlying …

Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …