Artificial intelligence, big data and machine learning approaches in precision medicine & drug discovery

A Nayarisseri, R Khandelwal, P Tanwar… - Current drug …, 2021 - ingentaconnect.com
Artificial Intelligence revolutionizes the drug development process that can quickly identify
potential biologically active compounds from millions of candidate within a short period. The …

Synthesis of antimicrobial benzimidazole–pyrazole compounds and their biological activities

M Marinescu - Antibiotics, 2021 - mdpi.com
The synthesis of new compounds with antimicrobial and antiviral properties is a central
objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole …

Novel hybrids of benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment

R Bhutani, DP Pathak, G Kapoor, A Husain… - Bioorganic chemistry, 2019 - Elsevier
A series of new benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …

Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti …

KRA Abdellatif, WAA Fadaly, GM Kamel… - Bioorganic …, 2019 - Elsevier
Nowadays, diabetes and its associated inflammatory complications are important public
health problems worldwide. Market limitations of drugs with dual actions as anti …

[HTML][HTML] An overview on medicinal perspective of thiazolidine-2, 4-dione: A remarkable scaffold in the treatment of type 2 diabetes

G Bansal, PV Thanikachalam, RK Maurya… - Journal of advanced …, 2020 - Elsevier
Diabetes or diabetes mellitus is a complex or polygenic disorder, which is characterized by
increased levels of glucose (hyperglycemia) and deficiency in insulin secretion or resistance …

Novel thiazolidin-4-one benzenesulfonamide hybrids as PPARγ agonists: Design, synthesis and in vivo anti-diabetic evaluation

IH Ali, RM Hassan, AM El Kerdawy… - European Journal of …, 2024 - Elsevier
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …

AC-SO3H/[CholineCl][Urea] 2 as a green catalytic system for the synthesis of pyrano [2, 3-c] pyrazole scaffolds

HT Nguyen, T Van Le, PH Tran - Journal of Environmental Chemical …, 2021 - Elsevier
A sulfonated amorphous carbon (AC-SO 3 H) was prepared from rice husk with sulfuric acid
and fully characterized using FT-IR spectroscopy, X-ray diffraction (XRD), scanning electron …

Design, synthesis and anti-hyperglycemic assessments of novel 5-benzylidenethiazolidine-2, 4-dione derivatives as PPAR-γ agonist

A Ali, A Ali, V Asati, S Kaya, MJ Ahsan - Journal of the Indian Chemical …, 2023 - Elsevier
The treatment of diabetes mellitus still relies predominantly on peroxisome proliferator-
activated receptor-γ (PPAR-γ) therapy, known for its effectiveness. In this present study, a …

Design, synthesis, DFT, molecular docking, and biological evalution of pyrazole derivatives as potent acetyl cholinestrease inhibitors

HE Abdelwahab, HZ Ibrahim, AZ Omar - Journal of Molecular Structure, 2023 - Elsevier
Alzheimer's disease (AD) is an age-related chronic and progressive neurodegenerative
disease, affecting cognition, memory, and behavior. Treatment of Alzheimer's disease's (AD) …

Design, synthesis and biological evaluation of novel 5-(imidazolyl-methyl) thiazolidinediones as antidiabetic agents

N Shakour, A Sahebkar, G Karimi, M Paseban… - Bioorganic …, 2021 - Elsevier
A newly designed series of imidazolyl-methyl-l-2, 4-thiazolidinediones 9 (am) were
synthesized and In Silico studies were carried out to rationalize their anti-diabetic activity …