Understanding the physical basis of memory: Molecular mechanisms of the engram

C Ortega-de San Luis, TJ Ryan - Journal of Biological Chemistry, 2022 - ASBMB
Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

[HTML][HTML] Transcriptome and epigenome analysis of engram cells: next-generation sequencing technologies in memory research

M Fuentes-Ramos, M Alaiz-Noya, A Barco - Neuroscience & Biobehavioral …, 2021 - Elsevier
Transcription and epigenetic changes are integral components of the neuronal response to
stimulation and have been postulated to be drivers or substrates for enduring changes in …

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis

S Zocher, RW Overall, G Berdugo‐Vega, N Rund… - The EMBO …, 2021 - embopress.org
Adult neurogenesis enables the life‐long addition of functional neurons to the hippocampus
and is regulated by both cell‐intrinsic molecular programs and behavioral activity. De novo …

Molecular and cellular mechanisms of engram allocation and maintenance

KG Karaca, J Kupke, AMM Oliveira - Brain Research Bulletin, 2021 - Elsevier
Understanding how we learn and remember has been a long-standing question in
neuroscience. Technological developments of the past 15 years have allowed for …

Unveiling Transcriptional and Epigenetic Mechanisms Within Engram Cells: Insights into Memory Formation and Stability

M Fuentes-Ramos, Á Barco - Engrams: A Window into the Memory Trace, 2024 - Springer
Memory traces for behavioral experiences, such as fear conditioning or taste aversion, are
believed to be stored through biophysical and molecular changes in distributed neuronal …

Engram Studies: A Call for Historical, Philosophical, and Sociological Approaches

L Chiapperino, F Panese - Engrams: A Window into the Memory Trace, 2024 - Springer
In this chapter, we identify three distinct avenues of research on the philosophical, historical,
and sociopolitical dimensions of engram research. First, we single out the need to refine …

Regions with intermediate DNA methylation are epigenomic hotspots governing behavioral adaptation to changing environments

E Brindley, F Taki, SC Odell, MR Baker, JG Toth… - bioRxiv, 2022 - biorxiv.org
Epigenetic and associated gene expression changes in the brain drive animals' ability to
adapt to changing environments. However, epigenetic attributes of environmental …

Epigenetic influences and brain development

PL Sokolov, NV Chebanenko, DM Mednaya - … and Behavioral Physiology, 2023 - Springer
Recent years have seen raid growth in the quantity of scientific data on the involvement of
epigenetic processes in regulating brain development during postnatal ontogenesis. This …

Analysis and Synthesis of Cellular Decision Making: Modeling Epigenetic Regulation in Cell Fate Networks and Designing a Distributed Synthetic Counter Circuit

T Chen - 2022 - search.proquest.com
How a genotype gives rise to a phenotype is a century-old question. In the developmental
biology of cancer, decades of research have discovered various essential factors …

From cellular to fear memory: An epigenetic toolbox to remember

DM Coda, J Gräff - Current Opinion in Neurobiology, 2024 - Elsevier
Throughout development, the neuronal epigenome is highly sensitive to external stimuli, yet
capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful …