Regulation of DEAH-box RNA helicases by G-patch proteins

KE Bohnsack, R Ficner, MT Bohnsack… - Biological Chemistry, 2021 - degruyter.com
RNA helicases of the DEAH/RHA family form a large and conserved class of enzymes that
remodel RNA protein complexes (RNPs) by translocating along the RNA. Driven by ATP …

Identification of common genetic risk variants for autism spectrum disorder

J Grove, S Ripke, TD Als, M Mattheisen, RK Walters… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

A hypothesis on the origin and evolution of tubulin

RF Ludueña - International review of cell and molecular biology, 2013 - Elsevier
Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and …

JC Bis, M Kavousi, N Franceschini, A Isaacs… - Nature …, 2011 - nature.com
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are
established measures of subclinical atherosclerosis that each predicts future cardiovascular …

Enterovirus 71 3C promotes apoptosis through cleavage of PinX1, a telomere binding protein

J Li, Y Yao, Y Chen, X Xu, Y Lin, Z Yang… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) is an emerging pathogen causing hand, foot, and mouth
disease (HFMD) and fatal neurological diseases in infants and young children due to their …

Shared genes between Alzheimer's disease and ischemic stroke

CJ Wei, P Cui, H Li, WJ Lang, GY Liu… - CNS Neuroscience & …, 2019 - Wiley Online Library
Aims Although converging evidence from experimental and epidemiological studies
indicates Alzheimer's disease (AD) and ischemic stroke (IS) are related, the genetic basis …

The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice

XZ Zhou, P Huang, R Shi, TH Lee, G Lu… - The Journal of …, 2011 - Am Soc Clin Investig
Telomerase is activated in most human cancers and is critical for cancer cell growth.
However, little is known about the significance of telomerase activation in chromosome …

Deciphering the combined effects of environmental stressors on gene transcription: a conceptual approach

Y Song, J Asselman… - … science & technology, 2018 - ACS Publications
The use of classical mixture toxicity models to predict the combined effects of environmental
stressors based on toxicogenomics (OMICS) data is still in its infancy. Although several …

The nuclear scaffold protein SAF-A is required for kinetochore–microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles

N Ma, S Matsunaga, A Morimoto… - Journal of cell …, 2011 - journals.biologists.com
Segregation of chromosomes during cell division requires correct formation of mitotic
spindles. Here, we show that a scaffold attachment factor A (SAF-A), also known as …

Chromatin protein HP1α interacts with the mitotic regulator borealin protein and specifies the centromere localization of the chromosomal passenger complex

X Liu, Z Song, Y Huo, J Zhang, T Zhu, J Wang… - Journal of Biological …, 2014 - ASBMB
Accurate mitosis requires the chromosomal passenger protein complex (CPC) containing
Aurora B kinase, borealin, INCENP, and survivin, which orchestrates chromosome …