Advances in anion transport and supramolecular medicinal chemistry

JT Davis, PA Gale, R Quesada - Chemical Society Reviews, 2020 - pubs.rsc.org
Advances in anion transport by synthetic supramolecular systems are discussed in this
article. Developments in the design of discrete molecular carriers for anions and …

Stimulus-controlled anion binding and transport by synthetic receptors

J de Jong, JE Bos, SJ Wezenberg - Chemical Reviews, 2023 - ACS Publications
Anionic species are omnipresent and involved in many important biological processes. A
large number of artificial anion receptors has therefore been developed. Some of these are …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

H Li, H Valkenier, AG Thorne, CM Dias, JA Cooper… - Chemical …, 2019 - pubs.rsc.org
Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One
approach to restore anion transport to CF cells utilises alternative pathways for …

Anion transporters based on halogen, chalcogen, and pnictogen bonds: towards biological applications

A Singh, A Torres-Huerta, F Meyer, H Valkenier - Chemical science, 2024 - pubs.rsc.org
Motivated by their potential biological applications, anion receptors are increasingly
explored as transmembrane transporters for anions. The vast majority of the reported anion …

Small-molecule drugs for cystic fibrosis: Where are we now?

O Laselva, L Guerra, S Castellani, M Favia… - Pulmonary …, 2022 - Elsevier
The cystic fibrosis (CF) lung disease is due to the lack/dysfunction of the CF Transmembrane
Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the …

Pharmacological modulation of ion channels for the treatment of cystic fibrosis

MC Pinto, IAL Silva, MF Figueira… - Journal of …, 2021 - Taylor & Francis
Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the gene
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …

Recent advances in bioactive artificial ionophores

A Roy, P Talukdar - ChemBioChem, 2021 - Wiley Online Library
Several life‐threatening diseases, also known as 'Channelopathies' are linked to
irregularities in ion transport proteins. Significant research efforts have fostered the …

[HTML][HTML] Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis

R Quesada, R Dutzler - Journal of Cystic Fibrosis, 2020 - Elsevier
Cystic fibrosis is a hereditary disease that originates from mutations in the epithelial chloride
channel CFTR. Whereas established therapies for the treatment of cystic fibrosis target …

Anti-Malassezia Drug Candidates Based on Virulence Factors of Malassezia-Associated Diseases

M Billamboz, S Jawhara - Microorganisms, 2023 - mdpi.com
Malassezia is a lipophilic unicellular fungus that is able, under specific conditions, to cause
severe cutaneous and systemic diseases in predisposed subjects. This review is divided …