Therapeutically harnessing extracellular vesicles

L Cheng, AF Hill - Nature Reviews Drug Discovery, 2022 - nature.com
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

[HTML][HTML] Exosome-based liquid biopsies in cancer: opportunities and challenges

W Yu, J Hurley, D Roberts, SK Chakrabortty… - Annals of …, 2021 - Elsevier
Liquid biopsy in cancer has gained momentum in clinical research and is experiencing a
boom for a variety of applications. There are significant efforts to utilize liquid biopsies in …

A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study

K Li, Y Lin, Y Luo, X Xiong, L Wang, K Durante, J Li… - Molecular cancer, 2022 - Springer
Background The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-
dependent manner in responses to variety of stresses that are common in cancers. We focus …

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

AM Leidal, HH Huang, T Marsh, T Solvik, D Zhang… - Nature cell …, 2020 - nature.com
Traditionally viewed as an autodigestive pathway, autophagy also facilitates cellular
secretion; however, the mechanisms underlying these processes remain unclear. Here, we …

New technologies for analysis of extracellular vesicles

H Shao, H Im, CM Castro, X Breakefield… - Chemical …, 2018 - ACS Publications
Extracellular vesicles (EVs) are diverse, nanoscale membrane vesicles actively released by
cells. Similar-sized vesicles can be further classified (eg, exosomes, microvesicles) based …

Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

A Amiri, R Bagherifar, E Ansari Dezfouli… - Journal of Translational …, 2022 - Springer
Nanocarriers as drug/biomolecule delivery systems have been significantly developed
during recent decades. Given the stability, reasonable delivery efficiency, and safety of …

Cells release subpopulations of exosomes with distinct molecular and biological properties

E Willms, HJ Johansson, I Mäger, Y Lee… - Scientific reports, 2016 - nature.com
Cells release nano-sized membrane vesicles that are involved in intercellular
communication by transferring biological information between cells. It is generally accepted …

Extracellular vesicles: composition, biological relevance, and methods of study

MŁP Zaborowski, L Balaj, XO Breakefield, CP Lai - Bioscience, 2015 - academic.oup.com
The release of extracellular vesicles (EVs), including exosomes and microvesicles, is a
phenomenon shared by many cell types as a means of communicating with other cells and …

Exosomes: from garbage bins to promising therapeutic targets

M H. Rashed, E Bayraktar, G K. Helal… - International journal of …, 2017 - mdpi.com
Intercellular communication via cell-released vesicles is a very important process for both
normal and tumor cells. Cell communication may involve exosomes, small vesicles of …