Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

In 2007, approximately 56 million units of blood were collected in developed countries. In
these countries (~ 25% of the world's population), the common risks associated with blood …

Carnosinases are Xaa-His dipeptidases that play diverse functions throughout all kingdoms
of life. Human isoforms of carnosinase (CN1 and CN2) under appropriate conditions …

Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species.
Carnosine is a naturally occurring dipeptide and has a scavenging property. The aim of …

Cisplatin is chemotherapeutic drug used in treatment of malignancies. However, its clinical
utility is limited by nephrotoxicity. The purpose of present study is to investigate biochemical …

The most common joint disease in the elderly is knee osteoarthritis (OA). It is distinguished
by cartilage degradation, subchondral bone loss, and a decrease in joint space. We studied …

The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …

Background Cisplatin (CP) is one of the effective anticancer drugs, but it causes many side
effects. Aged garlic extract (AGE) is a natural herbal product used in management of many …

Cisplatin (CP) is a chemotherapeutic drug used in treatment of malignancies. However, its
clinical utility is limited by nephrotoxicity. The purpose of the present study was to investigate …

Recently, we identified an allelic variant of human carnosinase 1 (CN1) that results in
increased enzyme activity and is associated with susceptibility for diabetic nephropathy in …