Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine protease
synthesized primarily by the liver. It mainly promotes the degradation of low-density …

Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies …

Hypercholesterolemia is a major risk factor for cardiovascular diseases, increasing the
incidence of myocardial infarction and death. Statin-induced lowering of low-density …

Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the
regulation of cholesterol homeostasis. By binding to hepatic low-density lipoprotein (LDL) …

The promise of precision medicine lies in data diversity. More than the sheer size of
biomedical data, it is the layering of multiple data modalities, offering complementary …

The discovery of bioactive molecules is an expensive and time-consuming process and new
strategies are continuously searched for in order to optimize this process. Virtual Screening …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …

Elevated LDL-cholesterol (LDLc) levels are a major risk factor for cardiovascular disease
and atherosclerosis. LDLc is cleared from circulation by the LDL receptor (LDLR). Proprotein …