Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases
The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
Translation and natural selection of micropeptides from long non-canonical RNAs
P Patraquim, EG Magny, JI Pueyo, AI Platero… - Nature …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but lacking
canonical coding sequences. Apparently unable to produce peptides, lncRNA function …
canonical coding sequences. Apparently unable to produce peptides, lncRNA function …
Genomics of cold adaptations in the Antarctic notothenioid fish radiation
Numerous novel adaptations characterise the radiation of notothenioids, the dominant fish
group in the freezing seas of the Southern Ocean. To improve understanding of the …
group in the freezing seas of the Southern Ocean. To improve understanding of the …
Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes
The origin of 'orphan'genes, species-specific sequences that lack detectable homologues,
has remained mysterious since the dawn of the genomic era. There are two dominant …
has remained mysterious since the dawn of the genomic era. There are two dominant …
Uncovering de novo gene birth in yeast using deep transcriptomics
WR Blevins, J Ruiz-Orera, X Messeguer… - Nature …, 2021 - nature.com
De novo gene origination has been recently established as an important mechanism for the
formation of new genes. In organisms with a large genome, intergenic and intronic regions …
formation of new genes. In organisms with a large genome, intergenic and intronic regions …
The properties, biotechnologies, and applications of antifreeze proteins
H Xiang, X Yang, L Ke, Y Hu - International journal of biological …, 2020 - Elsevier
By natural selection, organisms evolve different solutions to cope with extremely cold
weather. The emergence of an antifreeze protein gene is one of the most momentous …
weather. The emergence of an antifreeze protein gene is one of the most momentous …
Experimental characterization of de novo proteins and their unevolved random-sequence counterparts
De novo gene emergence provides a route for new proteins to be formed from previously
non-coding DNA. Proteins born in this way are considered random sequences and typically …
non-coding DNA. Proteins born in this way are considered random sequences and typically …
Antarctic blackfin icefish genome reveals adaptations to extreme environments
Abstract Icefishes (suborder Notothenioidei; family Channichthyidae) are the only
vertebrates that lack functional haemoglobin genes and red blood cells. Here, we report a …
vertebrates that lack functional haemoglobin genes and red blood cells. Here, we report a …
Mechanisms of protein evolution
How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …
structure, and in turn in function? This question has multiple angles, ranging from …