Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of the
bone. Defects in osteoclasts thus result in unbalanced bone remodeling, leading to …

The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein
kinase that integrates inputs from nutrients and growth factors to control many fundamental …

Specialized connective tissues, including bone and adipose tissues, control various
physiological activities, including mineral and energy homeostasis. However, the identity of …

Skeleton has emerged as an endocrine organ which is both capable of regulating energy
metabolism and being a target for it. Glutamine is the most bountiful and flexible amino acid …

Periodontal bone regeneration is a major challenge in the treatment of periodontitis.
Currently the main obstacle is the difficulty of restoring the regenerative vitality of periodontal …

Previous research indicates that kaempferol (Kae) promotes osteogenesis, but its underlying
mechanism of action remains unclear. The present study hypothesized that the osteogenic …

We show the first example of a synergic approach of oxidant (ROS) scavenging carrier and
ROS-responsive drug release in the context of a potential therapy against osteoporosis …

Leiomyosarcoma (LMS) is an aggressive, often poorly differentiated cancer of the smooth
muscle (SM) lineage for which the molecular drivers of transformation and progression are …

There is a significant clinical demand for bone repair materials with high efficacy. This study
was designed to fabricate nanofibrous scaffolds to promote bone defect regeneration using …

Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology
throughout their differentiation. Altered osteoclast differentiation and activity lead to changes …