The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …

Abstract Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major
complication of liver transplantation. Transmembrane member 16A (TMEM16A), a …

The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of
phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which …

Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell
death in many neurodegenerative diseases. How neurons die in these tauopathies is …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …

Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the gene
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …

As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct
tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows …

Background The ATP-gated ionotropic P2X7 receptor (P2X7R) has the unusual ability to
function as a small cation channel and a trigger for permeabilization of plasmalemmal …