Cyanobenzaldehye (also called 2‐formylbenzonitrile) and related 2‐acylbenzonitriles
belong to a class of bifunctional aromatic compounds that emerged as useful starting …

Most fungi generate secondary metabolites essential to their growth or used as chemical
defense systems. They produce a large variety of small molecules, notably alkaloids …

In previous studies, several isoindolin-1-one analogs that exhibited significant anti-tobacco
mosaic virus (anti-TMV) activities were isolated from Nicotiana tabacum. Since gene-editing …

The exploration of novel anticancer compounds based on natural cyclopeptides has
emerged as a pivotal paradigm in the contemporary advancement of macrocyclic …

The highly toxic and flammable nature of CO lead to high handling demand for its use and
storage, undoubtedly constricting its further academic exploration for carbonylative reactions …

We report herein a facile strategy to synthesize trifluoromethylated γ-lactams through
trifluoromethylcarbonylation of N-cyano alkenes using readily available CF3SO2Na as the …

Using chiral phosphoric acids as organocatalysts, a formal asymmetric (4+ 2) cycloaddition
of 3‐methylene isoindolinone and in situ‐generated ortho‐quinone methide substrates is …

We describe the electrochemical α-amidoalkylation of γ-lactams based on transition-metal-
free cross-coupling via hydrogen atom transfer. The highly selective hydrogen atom transfer …

Catalytic systems for direct C− H activation of arenes commonly show preference for
electronically activated and sterically exposed C− H sites. Here we show that a range of …

A small library of 3-hydroxyisoindolin-1-ones has been prepared from 3-alkylidenephtalides
under ultrasonic irradiation. This practical synthesis is featured by group tolerance, high …