The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …

Heterozygous mutations in the gene that encodes the transcription factor hepatocyte nuclear
factor 1β (HNF1B) represent the most common known monogenic cause of developmental …

Maturity-onset diabetes of the young (MODY) is a monogenic disorder that results in a
familial, young-onset non-insulin dependent form of diabetes, typically presenting in lean …

Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed
in tissues including renal epithelia, associate with abnormal renal development. While …

OBJECTIVE Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with
a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and …

Mutations in HNF1B are responsible for a dominantly inherited disease with renal and
nonrenal consequences, including maturity-onset diabetes of the young (MODY) type 5 …

Mutations in HNF1B, the gene encoding hepatocyte nuclear factor 1β are the most
commonly identified genetic cause of renal malformations. HNF1B was first identified as a …

The growing accessibility and falling costs of genetic sequencing techniques has expanded
the utilization of genetic testing in clinical practice. For living kidney donation, genetic …

HNF1B-related disease is an emerging condition characterized by an autosomal-dominant
inheritance, a 50% rate of de novo mutations, and a highly variable phenotype (renal …

Malformations of the kidney and lower urinary tract are the most frequent cause of end-stage
renal disease in children. Mutations in HNF1Β and PAX2 commonly cause syndromic …