Targeting innate immunity-driven inflammation in CKD and cardiovascular disease

T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Gut microbiota dysbiosis-associated obesity and its involvement in cardiovascular diseases and type 2 diabetes. A systematic review

N Hamjane, MB Mechita, NG Nourouti, A Barakat - Microvascular Research, 2023 - Elsevier
Introduction Obesity is a complex, multifactorial disease caused by various factors. Recently,
the role of the gut microbiota in the development of obesity and its complications has …

Innate immunity system in patients with cardiovascular and kidney disease

C Zoccali, F Mallamaci - Circulation research, 2023 - Am Heart Assoc
With a global burden of 844 million, chronic kidney disease (CKD) is now considered a
public health priority. Cardiovascular risk is pervasive in this population, and low-grade …

Vascular calcification: an important understanding in nephrology

S Zununi Vahed, S Mostafavi… - Vascular Health and …, 2020 - Taylor & Francis
Vascular calcification (VC) is a life-threatening state in chronic kidney disease (CKD). High
cardiovascular mortality and morbidity of CKD cases may root from medial VC promoted by …

Association of trimethylamine, trimethylamine N-oxide, and dimethylamine with cardiovascular risk in children with chronic kidney disease

CN Hsu, GP Chang-Chien, S Lin, CY Hou… - Journal of Clinical …, 2020 - mdpi.com
Chronic kidney disease (CKD) is associated with high risk for cardiovascular disease (CVD).
Gut microbiota-dependent metabolites trimethylamine (TMA), trimethylamine N-oxide …

Using machine learning to identify metabolomic signatures of pediatric chronic kidney disease etiology

AM Lee, J Hu, Y Xu, AG Abraham, R Xiao… - Journal of the …, 2022 - journals.lww.com
Background Untargeted plasma metabolomic profiling combined with machine learning
(ML) may lead to discovery of metabolic profiles that inform our understanding of pediatric …

Uremia-Induced Gut Barrier Defect in 5/6 Nephrectomized Mice Is Worsened by Candida Administration through a Synergy of Uremic Toxin, Lipopolysaccharide, and (1➔3)-β-D …

S Tungsanga, W Panpetch… - International Journal of …, 2022 - mdpi.com
A chronic kidney disease (CKD) causes uremic toxin accumulation and gut dysbiosis, which
further induces gut leakage and worsening CKD. Lipopolysaccharide (LPS) of Gram …

Effects of probiotics on inflammation and uremic toxins among patients on dialysis: a systematic review and meta-analysis

C Thongprayoon, W Kaewput, ST Hatch… - Digestive Diseases and …, 2019 - Springer
Abstract Background/Objectives We performed this systematic review and meta-analysis to
evaluate effects of probiotics on inflammation, uremic toxins, and gastrointestinal (GI) …

The New Nordic Renal Diet induces a pronounced reduction of urine acid excretion and uremic toxins in chronic kidney disease patients (stage 3 and 4)

NM Hansen, P Berg, M Rix, M Pareek, J Leipziger… - Journal of Renal …, 2023 - Elsevier
Objective Metabolic acidosis and the uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate
(PCS), are associated with increased risks of kidney disease progression, muscle …

Microbiome systems biology advancements for natural well-being

G Chatterjee, S Negi, S Basu, J Faintuch… - Science of The Total …, 2022 - Elsevier
Throughout the years all data from epidemiological, physiological and omics have
suggested that the microbial communities play a considerable role in modulating human …