Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Abstract DNMT1 (DNA methyltransferase 1) is the predominant member of the DNMT family
and the most abundant DNMT in various cell types. It functions as a maintenance DNMT and …

The serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases
Cdc42 and Rac, represent a group of important molecular switches linking the complex …

DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disease caused by upper
and lower motor neuron death. Despite advances in our understanding of ALS …

The balance of excitation and inhibition is essential for cortical information processing,
relying on the tight orchestration of the underlying subcellular processes. Dynamic …

Cell migration is a key process in health and disease. In the last decade an increasing
attention is given to chromatin organization in migrating cells. In various types of cells …

Epigenetic mechanisms of gene regulation, including DNA methylation and histone
modifications, call increasing attention in the context of development and human health …