When the damage is done: injury and repair in thymus function

S Kinsella, JA Dudakov - Frontiers in immunology, 2020 - frontiersin.org
Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or
common cancer therapies such as cytoreductive chemo-or radiation-therapy, it also has a …

Dynamics of thymus function and T cell receptor repertoire breadth in health and disease

D Granadier, L Iovino, S Kinsella… - Seminars in …, 2021 - Springer
T cell recognition of unknown antigens relies on the tremendous diversity of the T cell
receptor (TCR) repertoire; generation of which can only occur in the thymus. TCR repertoire …

Experimental pulmonary tuberculosis in the absence of detectable brain infection induces neuroinflammation and behavioural abnormalities in male balb/c mice

JV Lara-Espinosa, RA Santana-Martínez… - International Journal of …, 2020 - mdpi.com
Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive
inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous …

Immune disturbances in female genital tuberculosis and latent genital tuberculosis

JB Sharma, S Sharma, E Sharma… - American Journal of …, 2023 - Wiley Online Library
Background Female genital tuberculosis (FGTB), an important clinical sub‐type of extra‐
pulmonary tuberculosis (EPTB) is responsible for about 10% cases of infertility in India. Both …

Steroid hormone modulates the production of cathelicidin and human β-defensins in lung epithelial cells and macrophages promoting Mycobacterium tuberculosis …

SP Marin-Luevano, A Rodriguez-Carlos… - Tuberculosis, 2021 - Elsevier
Several studies have documented the interaction between the immune and endocrine
systems as an effective defense strategy against tuberculosis, involving the production of …

Inclusion complexation and liposomal encapsulation of an isoniazid hydrazone derivative in cyclodextrin for pH-dependent controlled release

JB Safari, LB Mona, BT Sekaleli, BKN Avudi… - Journal of Drug Delivery …, 2023 - Elsevier
Tuberculosis, a predominantly pulmonary pathology, is currently the deadliest infection
worldwide. Its treatment is based on combination therapy involving selected antimicrobials …

Differential expression of genes regulated by the glucocorticoid receptor pathway in patients with pulmonary tuberculosis

G Gallucci, A Díaz, RDV Fernandez, B Bongiovanni… - Life Sciences, 2022 - Elsevier
Aims Previous studies in TB patients showed an immuno-endocrine imbalance
characterized by a disease-severity associated increase in plasma levels of proinflammatory …

The functional significance of endocrine-immune interactions in health and disease

S Muthusami, B Vidya, EM Shankar… - Current Protein and …, 2020 - ingentaconnect.com
Hormones are known to influence various body systems that include skeletal, cardiac,
digestive, excretory, and immune systems. Emerging investigations suggest the key role …

RNA-Seq Transcriptome Analysis of Peripheral Blood From Cattle Infected With Mycobacterium bovis Across an Experimental Time Course

KE McLoughlin, CN Correia, JA Browne… - Frontiers in Veterinary …, 2021 - frontiersin.org
Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis
complex, particularly Mycobacterium bovis, is a major endemic disease affecting cattle …

Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune …

B Bongiovanni, S Marín-Luevano, L D'Attilio, A Díaz… - Cytokine, 2020 - Elsevier
Given the role of host defense peptides (HDPs) in the defensive response against
mycobacteria, we analyzed the circulating levels of LL-37, β-defensin-2 and-3 in newly …