Multiple functionalities of reduced flavin in the non-redox reaction catalyzed by UDP-galactopyranose mutase
Flavin cofactors are widely used by enzymes to catalyze a broad range of chemical
reactions. Traditionally, flavins in enzymes are regarded as redox centers, which enable …
reactions. Traditionally, flavins in enzymes are regarded as redox centers, which enable …
Exploring the catalytic mechanism of the RNA cap modification by nsp16-nsp10 complex of SARS-CoV-2 through a QM/MM approach
The inhibition of key enzymes that may contain the viral replication of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) have assumed central importance in …
respiratory syndrome coronavirus 2 (SARS-CoV-2) have assumed central importance in …
In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction
UDP-galactopyranose mutase (UGM) plays an essential role in galactofuranose
biosynthesis in pathogens by catalyzing the conversion of UDP-galactopyranose to UDP …
biosynthesis in pathogens by catalyzing the conversion of UDP-galactopyranose to UDP …
Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study
The dihydroorotate dehydrogenase (DHOD) enzyme catalyzes the unique redox reaction in
the de novo pyrimidine biosynthesis pathway. In this reaction, the oxidation of dihydroorotate …
the de novo pyrimidine biosynthesis pathway. In this reaction, the oxidation of dihydroorotate …
Molecular Dynamics Simulations of Substrate Release from Trypanosoma cruzi UDP-Galactopyranose Mutase
R Cossio-Pérez, G Pierdominici-Sottile… - Journal of chemical …, 2019 - ACS Publications
The enzyme UDP-galactopyranose mutase (UGM) represents a promising drug target for the
treatment of infections with Trypanosoma cruzi. We have computed the Potential of Mean …
treatment of infections with Trypanosoma cruzi. We have computed the Potential of Mean …
Steric control of the rate-limiting step of UDP-galactopyranose mutase
G Pierdominici-Sottile, R Cossio-Pérez… - Biochemistry, 2018 - ACS Publications
Galactose is an abundant monosaccharide found exclusively in mammals as
galactopyranose (Gal p), the six-membered ring form of this sugar. In contrast, galactose …
galactopyranose (Gal p), the six-membered ring form of this sugar. In contrast, galactose …
[PDF][PDF] Supporting Information In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction
EXPERIMENTAL PROCEDURES Site-Directed Mutagenesis and Protein Production.
Protein expression was performed using autoinduction media and following procedures …
Protein expression was performed using autoinduction media and following procedures …