Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …

Background Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in
particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds …

Although circular RNAs (circRNA) are known to modulate tumor initiation and progression,
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …

Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …

The tumour microenvironment (TME) constitutes the area surrounding the tumour during its
development and has been demonstrated to play roles in cancer-related diseases through …

Targeted treatment, which can specifically kill tumour cells without affecting normal cells, is a
new approach for tumour therapy. However, tumour cells tend to acquire resistance to …

Circular RNAs (circRNAs) are RNAs with a unique circular structure that is generated from
back-splicing processes. These circular molecules were discovered more than 40 years ago …