Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta… - Journal of medicinal …, 2017 - ACS Publications
Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis
AK Gardino, MB Yaffe - Seminars in cell & developmental biology, 2011 - Elsevier
14-3-3 proteins play critical roles in the regulation of cell fate through phospho-dependent
binding to a large number of intracellular proteins that are targeted by various classes of …
binding to a large number of intracellular proteins that are targeted by various classes of …
Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm
Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a
diversity of cellular processes during development but also plays a pivotal role in …
diversity of cellular processes during development but also plays a pivotal role in …
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: an update
Y Cau, D Valensin, M Mori, S Draghi… - Current medicinal …, 2018 - ingentaconnect.com
14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-
protein interactions (PPIs). They are usually found in all eukaryotes with a conserved …
protein interactions (PPIs). They are usually found in all eukaryotes with a conserved …
14-3-3 zeta as novel molecular target for cancer therapy
Introduction: 14-3-3ζ acts as a central hub in signaling networks, which promotes cell
proliferation, adhesion and survival and inhibits apoptosis in multiple cancers. Development …
proliferation, adhesion and survival and inhibits apoptosis in multiple cancers. Development …
[HTML][HTML] Mechanisms of acquired resistance to tyrosine kinase inhibitors
Y Chen, L Fu - Acta Pharmaceutica Sinica B, 2011 - Elsevier
In recent years, structural and functional studies reveal that tyrosine kinases (TKs) act as the
essential components of signal transduction pathways that regulate cancer cell proliferation …
essential components of signal transduction pathways that regulate cancer cell proliferation …
p73: From the p53 shadow to a major pharmacological target in anticancer therapy
H Ramos, L Raimundo, L Saraiva - Pharmacological research, 2020 - Elsevier
Abstract p73, along with p53 and p63, belongs to the p53 family of transcription factors.
Besides the p53-like tumor suppressive activities, p73 has unique roles, namely in neuronal …
Besides the p53-like tumor suppressive activities, p73 has unique roles, namely in neuronal …
14-3-3/Tau interaction and Tau amyloidogenesis
Y Chen, X Chen, Z Yao, Y Shi, J Xiong, J Zhou… - Journal of Molecular …, 2019 - Springer
The major function of microtubule-associated protein tau is to promote microtubule assembly
in the central nervous system. However, aggregation of abnormally phosphorylated tau is a …
in the central nervous system. However, aggregation of abnormally phosphorylated tau is a …
A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression
D Engelmann, C Meier, V Alla, BM Pützer - Oncogene, 2015 - nature.com
Abstract p73 is the older sibling of p53 and mimics most of its tumor-suppressor functions.
Through alternative promoter usage and splicing, the TP73 gene generates more than two …
Through alternative promoter usage and splicing, the TP73 gene generates more than two …