[HTML][HTML] Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data
Vortioxetine, a novel antidepressant for the treatment of major depressive disorder (MDD), is
a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial agonist, 5-HT …
a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial agonist, 5-HT …
Molecular aspects of depression: a review from neurobiology to treatment
GRV Boas, RB de Lacerda, MM Paes, P Gubert… - European journal of …, 2019 - Elsevier
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …
Possible role of exercise therapy on depression: effector neurotransmitters as key players
HA Pahlavani - Behavioural brain research, 2023 - Elsevier
About 280 million people suffer from depression as the most common neurological disorder
and the most common cause of death worldwide. Exercise with serotonin released in the …
and the most common cause of death worldwide. Exercise with serotonin released in the …
Structural basis for partial agonism in 5-HT3A receptors
K Felt, M Stauffer, L Salas-Estrada, PR Guzzo… - Nature Structural & …, 2024 - nature.com
Abstract Hyperactivity of serotonin 3 receptors (5-HT3R) underlies pathologies associated
with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a …
with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a …
Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters—a rat microdialysis and electrophysiology …
AL Pehrson, T Cremers, C Bétry… - European …, 2013 - Elsevier
The monoaminergic network, including serotonin (5-HT), norepinephrine (NE), and
dopamine (DA) pathways, is highly interconnected and has a well-established role in mood …
dopamine (DA) pathways, is highly interconnected and has a well-established role in mood …
[HTML][HTML] 5-HT3 receptor antagonism: a potential therapeutic approach for the treatment of depression and other disorders
Background Depression or Major depressive disorder (MDD) is a prolonged condition of
sadness. MDD is the most common mental disorder that affects more than 264 million …
sadness. MDD is the most common mental disorder that affects more than 264 million …
5-HT3 receptor antagonists in neurologic and neuropsychiatric disorders: the iceberg still lies beneath the surface
5-HT3 receptor antagonists, first introduced to the market in the mid-1980s, are proven
efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent …
efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent …
Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways
The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using
in vivo and in silico studies. To assess the effect, doses of 50 mg/kg bw copper sulfate …
in vivo and in silico studies. To assess the effect, doses of 50 mg/kg bw copper sulfate …
Phenotypic distinctions in depression and anxiety: a comparative analysis of comorbid and isolated cases
BackgroundAnxiety and depression are frequently comorbid yet phenotypically distinct. This
study identifies differences in the clinically observable phenome across a wide variety of …
study identifies differences in the clinically observable phenome across a wide variety of …
Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor
Abstract Serotonin receptor (5-HT3AR) is the most common therapeutic target to manage the
nausea and vomiting during cancer therapies and in the treatment of irritable bowel …
nausea and vomiting during cancer therapies and in the treatment of irritable bowel …