The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the
signal transduction and cooperative properties of bacterial regulatory enzymes and …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

Motivation: Molecular simulation has historically been a low-throughput technique, but faster
computers and increasing amounts of genomic and structural data are changing this by …

Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …

Molecular simulations are an invaluable tool for understanding membrane proteins.
Improvements to both hardware and simulation methods have allowed access to …

Ethanol alters nerve signalling by interacting with proteins in the central nervous system,
particularly pentameric ligand-gated ion channels. A recent series of mutagenesis …

Alcohol dependence is a complex condition with clear genetic factors. Some of the leading
candidate genes code for subunits of the inhibitory GABA A and glycine receptors. These …

Despite its long history of use and abuse in human culture, the molecular basis for alcohol
action in the brain is poorly understood. The recent determination of the atomic-scale …

Despite the clinical ubiquity of anesthesia, the molecular basis of anesthetic action is poorly
understood. Amongst the many molecular targets proposed to contribute to anesthetic …

A brief historical overview of the concept of allosteric interaction is presented together with
the different kinds of allosteric control recognized, in the past decades, with the model …