Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

The need for clean air: the way air pollution and climate change affect allergic rhinitis and asthma

I Eguiluz‐Gracia, AG Mathioudakis, S Bartel… - Allergy, 2020 - Wiley Online Library
Air pollution and climate change have a significant impact on human health and well‐being
and contribute to the onset and aggravation of allergic rhinitis and asthma among other …

Growth factor delivery: Defining the next generation platforms for tissue engineering

LMC Aguilar, SM Silva, SE Moulton - Journal of controlled Release, 2019 - Elsevier
Growth factors play a crucial role in tissue engineering by directing the fate of cells and
allowing the formation of tissues. Understanding the key requirements for growth factor …

Neutrophils and asthma

A Yamasaki, R Okazaki, T Harada - Diagnostics, 2022 - mdpi.com
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic
inflammation is also marked, and eosinophils and neutrophils can coexist in some cases …

Realigning the LIGHT signaling network to control dysregulated inflammation

CF Ware, M Croft, GA Neil - Journal of Experimental Medicine, 2022 - rupress.org
Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …

TGF-β signaling in health, disease, and therapeutics

Z Deng, T Fan, C Xiao, H Tian, Y Zheng, C Li… - Signal transduction and …, 2024 - nature.com
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …

Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies

T Liu, PG Woodruff, X Zhou - European Respiratory Journal, 2024 - publications.ersnet.org
Asthma is a prevalent pulmonary disease that affects more than 300 million people
worldwide and imposes a substantial economic burden. While medication can effectively …

Immunologic and non-immunologic mechanisms leading to airway remodeling in asthma

L Fang, Q Sun, M Roth - International journal of molecular sciences, 2020 - mdpi.com
Asthma increases worldwide without any definite reason and patient numbers double every
10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but …

Mechanism of rhinovirus immunity and asthma

Z Yang, H Mitländer, T Vuorinen, S Finotto - Frontiers in immunology, 2021 - frontiersin.org
The majority of asthma exacerbations in children are caused by Rhinovirus (RV), a positive
sense single stranded RNA virus of the Picornavirus family. The host has developed virus …

Rhinovirus induces airway remodeling: what are the physiological consequences?

C Spector, CM De Sanctis, RA Panettieri Jr… - Respiratory …, 2023 - Springer
Background Rhinovirus infections commonly evoke asthma exacerbations in children and
adults. Recurrent asthma exacerbations are associated with injury-repair responses in the …