The fibroblast growth factor signaling pathway
DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Targeting FGFR signaling in cancer
The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …
conserved signaling cascade that regulates several basic biologic processes, including …
[HTML][HTML] The role of the ALK receptor in cancer biology
B Hallberg, RH Palmer - Annals of Oncology, 2016 - Elsevier
ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …
Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance
Structural gene rearrangements resulting in gene fusions are frequent events in solid
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
B Hallberg, RH Palmer - Nature Reviews Cancer, 2013 - nature.com
The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …
[HTML][HTML] Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors
The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
[HTML][HTML] Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Fusions of the RET and ROS1 protein tyrosine kinase oncogenes with several partner genes
were recently identified as new targetable genetic aberrations in cases of non-small cell …
were recently identified as new targetable genetic aberrations in cases of non-small cell …
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
We identified new gene fusions in patients with lung cancer harboring the kinase domain of
the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein) …
the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein) …
Detection, characterization, and inhibition of FGFR–TACC fusions in IDH wild-type glioma
AL Di Stefano, A Fucci, V Frattini, M Labussiere… - Clinical cancer …, 2015 - AACR
Purpose: Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and
TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have …
TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have …
Tyrosine kinase gene rearrangements in epithelial malignancies
Chromosomal rearrangements that lead to oncogenic kinase activation are observed in
many epithelial cancers. These cancers express activated fusion kinases that drive the …
many epithelial cancers. These cancers express activated fusion kinases that drive the …