An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment

E Verdugo, I Puerto, MÁ Medina - Cancer Communications, 2022 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most aggressive and common malignant primary brain
tumor. Patients with GBM often have poor prognoses, with a median survival of∼ 15 months …

Advances in glioblastoma therapy: an update on current approaches

RS Angom, NMR Nakka, S Bhattacharya - Brain sciences, 2023 - mdpi.com
Glioblastoma multiforme (GBM) is a primary malignant brain tumor characterized by a high
grade of malignancy and an extremely unfavorable prognosis. The current efficacy of …

Cytotoxic effect of diferuloylmethane, a derivative of turmeric on different human glioblastoma cell lines

I Bilal, S Xie, MS Elburki, Z Aziziaram… - Cellular, Molecular …, 2021 - cmbr-journal.com
Glioblastoma is a fatal brain tumor, and the standard treatment for this cancer is the surgical
removal of the tumor followed by chemotherapy with temozolomide and radiotherapy …

The complexities underlying epilepsy in people with glioblastoma

E Sokolov, J Dietrich, AJ Cole - The Lancet Neurology, 2023 - thelancet.com
Seizures are among the most common clinical signs in people with glioblastoma. Advances
over the past 5 years, including new clinical trial data, have increased the understanding of …

Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers

N Rabah, FE Ait Mohand… - International Journal of …, 2023 - mdpi.com
The most prevalent and aggressive type of brain cancer, namely, glioblastoma (GBM), is
characterized by intra-and inter-tumor heterogeneity and strong spreading capacity, which …

Characterization of different subtypes of immune cell infiltration in glioblastoma to aid immunotherapy

P Feng, Z Li, Y Li, Y Zhang, X Miao - Frontiers in Immunology, 2022 - frontiersin.org
Glioblastoma multiforme (GBM) has been identified as a frequently occurring adult primary
brain cancer that is highly aggressive. Currently, the prognostic outcome for GBM patients is …

The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug …

D Hussein, R Alsereihi, AAA Salwati, R Algehani… - Cancer cell …, 2022 - Springer
Abstract Background Glioblastomas (GBs) are characterised as one of the most aggressive
primary central nervous system tumours (CNSTs). Single-cell sequencing analysis identified …

Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

H Zhang, Y Du, L Qi, S Xiao, FK Braun… - Journal of Translational …, 2023 - Springer
Background Animal models representing different molecular subtypes of glioblastoma
multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus …

Gene expression profiling of glioblastoma to recognize potential biomarker candidates

Q Li, S Aishwarya, JP Li, DX Pan, JP Shi - Frontiers in genetics, 2022 - frontiersin.org
Glioblastoma is an aggressive malignant tumor of the brain and spinal cord. Due to the
blood–brain barrier, the accessibility of its treatments still remains significantly challenging …

A novel necroptosis-related gene signature for predict prognosis of glioma based on single-cell and bulk RNA sequencing

K Guo, X Duan, J Zhao, B Sun, X Liu… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: Glioma is the most fatal neoplasm among the primary intracranial cancers.
Necroptosis, a form of programmed cell death, is correlated with tumor progression and …