Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

Epigenetic association studies have been carried out to test the hypothesis that
environmental perturbations trigger cellular reprogramming, with downstream effects on …

Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …

Studies on genetic–epigenetic interactions, including the mapping of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …

Over the past decades, genome-wide association studies (GWAS) have identified thousands
of phenotype-associated DNA sequence variants for potential explanations of inter …

Eight syndromes are associated with the loss of methylation at specific imprinted loci. There
has been increasing evidence that these methylation defects in patients are not isolated …

Background Maternal effect mutations in the components of the subcortical maternal
complex (SCMC) of the human oocyte can cause early embryonic failure, gestational …

DNA methylation is an essential epigenetic mark crucial for normal mammalian
development. This modification controls the expression of a unique class of genes …

In viviparous mammals, genomic imprinting regulates parent-of-origin-specific monoallelic
expression of paternally and maternally expressed imprinted genes (PEGs and MEGs) in a …

ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control
regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICRBS) and …