Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

The neural circuits governing vital behaviors, such as respiration and locomotion, are
comprised of discrete neuronal populations residing within the brainstem and spinal cord …

A targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …

The AP-1 transcription factor c-Jun is a master regulator of the axonal response in neurons.
c-Jun also functions as a negative regulator of myelination in Schwann cells (SCs) and is …

Eph receptors and their membrane-tethered ligands have important functions in
development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote …

Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

Peripheral nerve damage initiates a complex series of structural and cellular processes that
culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) …