Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

Nicotinamide riboside is a precursor to the important cofactor nicotinamide adenine
dinucleotide and has elicited metabolic benefits in multiple preclinical studies. In 2016, the …

The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …

Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result
from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age …

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

Advancing age and many disease states are associated with declines in nicotinamide
adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ …

Ageing is characterized by the progressive loss of cellular homeostasis, leading to an
overall decline of the organism's fitness. In the brain, ageing is highly associated with …

Abstract Background Cognitive decline in Alzheimer's disease (AD) is associated with
hyperphosphorylated tau (pTau) propagation between neurons along synaptically …

Abstract Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox
reactions, is closely associated with age-related functional degeneration and metabolic …

NAD+ is crucial for cellular balance in all organisms. Recent interest has focused on its
metabolism. Deficiency-related issues can be countered using NMN and NR, potential …