BACKGROUND Cyclins and cyclin-dependent kinases (CDKs) drive cell division. Of
particular importance to the cancer field are D-cyclins, which activate CDK4 and CDK6. In …

Biochemical and genetic characterization of D-type cyclins, their cyclin D–dependent
kinases (CDK4 and CDK6), and the polypeptide CDK4/6 inhibitor p16INK4 over two …

Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and
associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1 …

We evaluated the safety, pharmacokinetic profile, pharmacodynamic effects, and antitumor
activity of abemaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDK) 4 …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Cellular growth, development, and differentiation are tightly controlled by a conserved
biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent …

Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can
modulate gene activity in response to external stimuli, but the scope and functions of such …

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically
acquired damage to genes that directly regulate their cell cycles. Genetic alterations …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …