The comet assay is a versatile method to detect nuclear DNA damage in individual
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …

Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

This article provides recommendations for the care of laboratory zebrafish (Danio rerio) as
part of the further implementation of Annex A to the European Convention on the protection …

Exosomes are extracellular vesicles of endosomal origin that are released by practically all
cell types across metazoans. Exosomes are active vehicles of intercellular communication …

This study investigated the direct and indirect toxic effects of microplastics and nanoplastics
toward zebrafish (Danio rerio) larvae locomotor activity. Results showed that microplastics …

The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

To discover new molecules or review the biological activity and toxicity of therapeutic
substances, drug development, and research relies on robust biological systems to obtain …

Burn wounds are often complicated by bacterial infection, contributing to morbidity and
mortality. Agents commonly used to treat burn wound infection are limited by toxicity …

Abstract Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio
rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for …

Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range
of industries, such as medicine, electronics and chemistry. In the current era, the commercial …