Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced
morbidity and mortality associated with HIV-1. Initially there was hope that ART would be …

HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …

Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …

Antiretroviral treatment (ART) of HIV infection suppresses viral replication. Yet if ART is
stopped, virus reemerges because of the persistence of infected cells. We evaluated the …

BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …

The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent
proviruses. To characterize these latently infected cells, we studied the integration profile of …

HIV-1 infection produces a long-lived reservoir of latently infected CD4+ T cells that
represents the major barrier to HIV-1 cure. The reservoir contains both intact and defective …

After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a
long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues …

HIV-1–infected individuals harbor a latent reservoir of infected CD4+ T cells that is not
eradicated by antiretroviral therapy (ART). This reservoir presents the greatest barrier to an …