Cell-penetrating peptides: Emerging tools for mRNA delivery

H Yokoo, M Oba, S Uchida - Pharmaceutics, 2021 - mdpi.com
Messenger RNAs (mRNAs) were previously shown to have great potential for preventive
vaccination against infectious diseases and therapeutic applications in the treatment of …

Membrane internalization mechanisms and design strategies of arginine-rich cell-penetrating peptides

M Hao, L Zhang, P Chen - International Journal of Molecular Sciences, 2022 - mdpi.com
Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

C Rinoldi, SS Zargarian, P Nakielski, X Li… - Small …, 2021 - Wiley Online Library
In recent years, the main quest of science has been the pioneering of the groundbreaking
biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids …

[HTML][HTML] Enhancing non-viral DNA delivery systems: Recent advances in improving efficiency and target specificity

M Hosseini-Kharat, KE Bremmell… - Journal of Controlled …, 2025 - Elsevier
DNA-based therapies are often limited by challenges such as stability, long-term integration,
low transfection efficiency, and insufficient targeted DNA delivery. This review focuses on …

Effect of helicity and hydrophobicity on cell-penetrating ability of arginine-rich peptides

M Oba, S Nakajima, K Misao, H Yokoo… - Bioorganic & Medicinal …, 2023 - Elsevier
Arginine (Arg)-rich peptides are one of the typical cell-penetrating peptides (CPPs), which
can deliver membrane-impermeable compounds into intracellular compartments. Guanidino …

The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution

A Kachanov, A Kostyusheva, S Brezgin… - Medicinal Research …, 2024 - Wiley Online Library
Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …

Oligosarcosine conjugation of arginine-rich peptides improves the intracellular delivery of peptide/pDNA complexes

H Yokoo, A Dirisala, S Uchida… - ACS Biomaterials Science …, 2023 - ACS Publications
Cell-penetrating peptides (CPPs), for example, arginine (Arg) rich peptides, are used for the
intracellular delivery of nucleic acids. In this study, oligosarcosine–conjugated Arg-rich …

Synthetic biodegradable polymeric materials in non-viral gene delivery

SS Panchal, DV Vasava - International Journal of Polymeric …, 2024 - Taylor & Francis
A vital trial in gene delivery implicates the want for competent and safe delivery systems to
announce therapeutic genes into target cells. Virus vectors are disparaged for genetic …

siRNA delivery using amphipathic cell-penetrating peptides into human hepatoma cells

K Furukawa, M Tanaka, M Oba - Bioorganic & medicinal chemistry, 2020 - Elsevier
Cell-penetrating peptides (CPPs) are an attractive tool for delivering membrane-
impermeable compounds, including anionic biomacromolecules such as DNA and RNA …

Helical foldamers and stapled peptides as new modalities in drug discovery: modulators of protein-protein interactions

K Tsuchiya, T Kurohara, K Fukuhara, T Misawa… - Processes, 2022 - mdpi.com
A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure
consisting of various building blocks. A “stapled peptide” is a peptide with stabilized …