The dogma that the genesis of new cells is a negligible event in the adult mammalian brain
has long influenced our perception and understanding of the origin and development of …

Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients.
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …

To isolate high-quality human postnatal stem cells from accessible resources is an important
goal for stem-cell research. In this study we found that exfoliated human deciduous tooth …

Transformed stem cells have been isolated from some human cancers. We report that,
unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors …

One of the impediments to the treatment of brain tumors (eg, gliomas) has been the degree
to which they expand, infiltrate surrounding tissue, and migrate widely into normal brain …

The poor survival of patients with human malignant gliomas relates partly to the inability to
deliver therapeutic agents to the tumor. Because it has been suggested that circulating bone …

Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and
neurodegenerative diseases. Although recent data show that cultured glioma cells secrete …

The prognosis of patients with malignant glioma is extremely poor, despite the extensive
surgical treatment that they receive and recent improvements in adjuvant radio-and …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …