The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs),
namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 …

Alkylamides (alkamides) from Echinacea modulate tumor necrosis factor α mRNA
expression in human monocytes/macrophages via the cannabinoid type 2 (CB 2) receptor …

The field of drug–membrane interactions is one that spans a wide range of scientific
disciplines, from synthetic chemistry, through biophysics to pharmacology. Cell membranes …

Modulation of neurotransmitter release by G-protein-coupled receptors (GPCRs) is a
prominent presynaptic mechanism for regulation of synaptic transmission. Activation of …

Endocannabinoids play an important role in a diverse range of neurophysiological
processes including neural development, neuroimmune function, synaptic plasticity, pain …

British scientists have played a leading role in the long history of cannabinoid and
endocannabinoid research. Such research has progressed from the first crucial evaluation …

Autism Spectrum Disorder (ASD) represents a distinct phenotype of behavioral dysfunction
that includes deficiencies in communication and stereotypic behaviors. ASD affects about …

Cannabinoids in current use such as nabilone activate both CB1 and CB2 receptors.
Selective CB2 activation may provide some of the therapeutic effects of cannabinoids, such …

Endogenous neurosteroids and their synthetic analogs (neuroactive steroids) are potent
modulators of GABA A receptors. Thus, they are of physiological and clinical relevance for …