Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Processing of DNA in replication, repair and recombination pathways in cells of all
organisms requires the participation of at least one major single-stranded DNA (ssDNA) …

The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …

Replication protein A (RPA) is the main eukaryotic ssDNA-binding protein with essential
roles in DNA replication, recombination, and repair. RPA maintains the DNA as single …

BRCA2 is the product of a breast cancer susceptibility gene in humans and the founding
member of an emerging family of proteins present throughout the eukaryotic domain that …

A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss
of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however …

Defects in cellular DNA metabolism have a direct role in many human disease processes.
Impaired responses to DNA damage and basal DNA repair have been implicated as causal …

DNA double-strand breaks (DSB) are presumed to be the most deleterious DNA lesions as
they disrupt both DNA strands. Homologous recombination (HR), single-strand annealing …

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much
progress has been made on elucidating critical roles for RPA in other DNA metabolic …

Rad52 promotes the annealing of complementary strands of DNA bound by replication
protein A (RPA) during discrete repair pathways. Here, we used a fluorescence resonance …