The conjugation of the 76 amino acid protein ubiquitin to other proteins can alter the
metabolic stability or non-proteolytic functions of the substrate. Once attached to a substrate …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

The SUMO protease SENP6 maintains genomic stability, but mechanistic understanding of
this process remains limited. We find that SENP6 deconjugates SUMO2/3 polymers on a …

Mitophagy refers to the process of selective removal of damaged or superfluous
mitochondria via the autophagy/lysosome pathway. In the past decade the molecular …

DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. To protect genomic
stability and ensure cell homeostasis, cells mount a complex signaling-based response that …

An inability to repair DNA double-strand breaks (DSBs) threatens genome integrity and can
contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly …

GCNA proteins are expressed across eukarya in pluripotent cells and have conserved
functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein …

All organisms depend on the ability of cells to accurately duplicate and segregate DNA into
progeny. However, DNA is frequently damaged by factors in the environment and from …

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …

Maintaining stability of the genome requires dedicated DNA repair and signalling processes
that are essential for the faithful duplication and propagation of chromosomes. These DNA …