[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis

C Young, G Walzl, N Du Plessis - Mucosal immunology, 2020 - Elsevier
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …

Totally drug‐resistant tuberculosis and adjunct therapies

SK Parida, R Axelsson‐Robertson… - Journal of internal …, 2015 - Wiley Online Library
The first cases of totally drug‐resistant (TDR) tuberculosis (TB) were reported in Italy 10
years ago; more recently, cases have also been reported in Iran, India and South Africa …

[HTML][HTML] Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury

F Fang, GC Liu, X Zhou, S Yang, HN Reich, V Williams… - PloS one, 2013 - journals.plos.org
Ischemia-reperfusion (I/R) is a model of acute kidney injury (AKI) that is characterized by
vasoconstriction, oxidative stress, apoptosis and inflammation. Previous studies have shown …

Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells

JS Kim, WS Kim, HG Choi, B Jang, K Lee… - Journal of leukocyte …, 2013 - academic.oup.com
The failure of Mycobacterium bovis BCG as a TB vaccine against TB reactivation suggests
that latency-associated proteins should be included in alternative TB vaccine development …

Bolstering immunity through pattern recognition receptors: a unique approach to control tuberculosis

S Pahari, G Kaur, M Aqdas, S Negi… - Frontiers in …, 2017 - frontiersin.org
The global control of tuberculosis (TB) presents a continuous health challenge to mankind.
Despite having effective drugs, TB still has a devastating impact on human health …

TB-IRIS, T-cell activation, and remodeling of the T-cell compartment in highly immunosuppressed HIV-infected patients with TB

V Haridas, P Pean, LD Jasenosky, Y Madec… - Aids, 2015 - journals.lww.com
Objective: To investigate the impact of tuberculosis-associated immune reconstitution
inflammatory syndrome (TB-IRIS) upon immunological recovery and the T-cell compartment …

Toll-like receptor-mediated innate immune responses by recognition of the recombinant dormancy-associated Mycobacterium tuberculosis proteins Rv2659c and …

C Saelee, J Hanthamrongwit, PT Soe, P Khaenam… - PloS one, 2022 - journals.plos.org
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) poses a major threat to the
global public health. Importantly, latent tuberculosis infection (LTBI) still impedes the …

Macrophage-and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses

O Epaulard, L Adam, C Poux, G Zurawski… - The Journal of …, 2014 - journals.aai.org
Dendritic cells are major APCs that can efficiently prime immune responses. However, the
roles of skin-resident Langerhans cells (LCs) in eliciting immune responses have not been …

Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study

T Ziypak, Z Halici, E Alkan, E Akpinar, B Polat… - Renal failure, 2015 - Taylor & Francis
Purpose: To determine the protective effect of aliskiren on ischemia–reperfusion (I/R) injury
in a rat renal (I/R) model. Methods: Rats were randomly divided into five groups: sham …

Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody

D Dangaj, KL Abbott, A Mookerjee, A Zhao, PS Kirby… - Plos one, 2011 - journals.plos.org
Tumor-infiltrating macrophages respond to microenvironmental signals by developing a
tumor-associated phenotype characterized by high expression of mannose receptor (MR …