Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes
resistant and requires more potent therapies. One mechanism of resistance observed in …

Abstract Introduction Ten percent of NSCLCs harbor mutations in SMARCA4, the gene
encoding the SWItch/Sucrose Non-Fermentable ATPase BRG1. In preclinical models, BRG1 …

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …

Genes encoding subunits of SWItch/Sucrose Non-Fermenting (SWI/SNF) chromatin
remodeling complexes are collectively mutated in 20% of all human cancers, among which …

Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure.
These multisubunit enzymes are heterogeneous in composition; there are two catalytic …

Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …

Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many
cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence …

A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas,
and waste exchanges between the maternal and fetal circulations and is an important …