The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

A Lismer, S Kimmins - Nature communications, 2023 - nature.com
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Effects of the global coronavirus disease-2019 pandemic on early childhood development: short-and long-term risks and mitigating program and policy actions

H Yoshikawa, AJ Wuermli, PR Britto, B Dreyer… - The Journal of …, 2020 - jpeds.com
(COVID-19) pandemic has led to huge societal public health and economic challenges
worldwide. The clinical effects of COVID-19 on young children are uncertain when …

The role of the epididymis and the contribution of epididymosomes to mammalian reproduction

ER James, DT Carrell, KI Aston, TG Jenkins… - International Journal of …, 2020 - mdpi.com
It is well-established that testicular spermatozoa are immature and acquire motility and
fertilization capabilities during transit throughout the epididymis. The epididymis is a duct …

Contribution of semen to early embryo development: fertilization and beyond

M Vallet-Buisan, R Mecca, C Jones… - Human …, 2023 - academic.oup.com
BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

Y Zhang, L Ren, X Sun, Z Zhang, J Liu, Y Xin… - Nature …, 2021 - nature.com
Paternal environmental inputs can influence various phenotypes in offspring, presenting
tremendous implications for basic biology and public health and policy. However, which …

Soma-to-germline RNA communication

CC Conine, OJ Rando - Nature Reviews Genetics, 2022 - nature.com
More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

[HTML][HTML] Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance …

CJ Li, QH Fang, ML Liu, JN Lin - Theranostics, 2020 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) including exosomes, microvesicles (MVs), and apoptotic bodies,
are small membrane vesicular structures that are released during cell activation …

Biological embedding of early-life adversity and a scoping review of the evidence for intergenerational epigenetic transmission of stress and trauma in humans

A Zhou, J Ryan - Genes, 2023 - mdpi.com
Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …

Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review

C Eberle, MF Kirchner, R Herden, S Stichling - PLoS One, 2020 - journals.plos.org
Background There is lots of evidence that maternal peri-gestational metabolic, genomic and
environmental conditions are closely linked to metabolic and cardiovascular outcomes in …