Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of
individual cell clones that encounter their cognate antigen. More recently, however, there is …

Because of the large preexisting antigenic load and immunosuppressive environment within
a tumor, inducing therapeutically useful antitumor immunity in cancer patients requires the …

Apoptosis can be mediated by different mechanisms. There is growing evidence that
different proteolytic enzymes are involved in the regulation of apoptosis. Cathepsins are …

The cytotoxic T-cell response in chronic hepatitis B virus (HBV) infection has been described
as weak and mono-or oligospecific in comparison to the more robust virus-specific T-cell …

Background & Aims: Cytotoxic T cells have been suggested to be responsible for lysis of
hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency …

T lymphocyte recognition of infected cells is mediated by T cell receptors (TCRs) interacting
with their ligands, self–major histocompatibility complex (MHC) molecules complexed with …

A majority of the human tumor-associated Ags characterized to date are derived from
nonmutated “self”-proteins. Little is currently understood about the nature of the self-reactive …

The forces that govern clonal selection during the genesis and maintenance of specific T cell
responses are complex, but amenable to decryption by interrogation of constituent …