Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …

The structural resemblance between the fused imidazopyridine heterocyclic ring system and
purines has prompted biological investigations to assess their potential therapeutic …

The ensemble of aminoacyl tRNA synthetases is regarded as a key component of the
protein translation machinery. With the progressive increase in structure-based studies on …

Aminoacyl-tRNA synthetases (aaRSs) are promising drug targets due to their essential roles
in protein translation. Although current inhibitors primarily occupy one or two of the three …

Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in
low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug …

The intestinal protozoan Cryptosporidium is a leading cause of diarrheal disease and
mortality in young children. There is currently no fully effective treatment for …

Antibiotic-resistant bacteria are widespread and pose a growing threat to human health.
New antibiotics acting by novel mechanisms of action are needed to address this challenge …

People from low-income countries are increasingly affected by neglected communicable
diseases, and the health care system frequently overlooks their needs. Currently, these …

Threonyl-tRNA synthetase (ThrRS) is a key member of the aminoacyl-tRNA synthetase
(aaRS) family that plays essential roles in protein biosynthesis, and ThrRS inhibitors have …

The synthesis of 5 H-imidazo [4, 5-c] pyridines analogues (1a− 1h) and 4 H-imidazo [4, 5-b]
pyridines (3a− 3c) was achieved by reacting 3, 4-diaminopyridine or 2, 3-diaminopyridine …