Vascular smooth muscle cells in atherosclerosis

GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease

P Lacolley, V Regnault, P Segers… - Physiological …, 2017 - journals.physiology.org
The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

A Frismantiene, M Philippova, P Erne, TJ Resink - Cellular signalling, 2018 - Elsevier
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

[HTML][HTML] Endothelial glycocalyx

CA Foote, RN Soares, FI Ramirez-Perez… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis

S Feil, B Fehrenbacher, R Lukowski… - Circulation …, 2014 - Am Heart Assoc
Rationale: Atherosclerosis is a widespread and devastating disease, but the origins of cells
within atherosclerotic plaques are not well defined. Objective: To investigate the specific …

[HTML][HTML] Pericytes: developmental, physiological, and pathological perspectives, problems, and promises

A Armulik, G Genové, C Betsholtz - Developmental cell, 2011 - cell.com
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …

Smooth muscle cell phenotypic switching in atherosclerosis

D Gomez, GK Owens - Cardiovascular research, 2012 - academic.oup.com
Smooth muscle cells (SMCs) possess remarkable phenotypic plasticity that allows rapid
adaptation to fluctuating environmental cues, including during development and progression …

Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease

MR Alexander, GK Owens - Annual review of physiology, 2012 - annualreviews.org
The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

Y Yao, ZL Chen, EH Norris, S Strickland - Nature communications, 2014 - nature.com
Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to
many neurological disorders, including stroke and Alzheimer's disease. How the basement …

[HTML][HTML] Specification and diversification of pericytes and smooth muscle cells from mesenchymoangioblasts

A Kumar, SS D'Souza, OV Moskvin, H Toh, B Wang… - Cell reports, 2017 - cell.com
Elucidating the pathways that lead to vasculogenic cells, and being able to identify their
progenitors and lineage-restricted cells, is critical to the establishment of human pluripotent …