Classical dendritic cells (cDCs) form a critical interface between innate and adaptive
immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of …

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune
responses according to peripheral cues. After four decades of research, we now know that …

B and T lymphocytes are the mediators of immunity, but their function is under the control of
dendritic cells. Dendritic cells in the periphery capture and process antigens, express …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells,
and natural killer (NK) cells remains controversial and constitutes an important gap in the …

Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are
many variations on this basic theme. DCs differ in the regulatory signals they transmit …

Toll-like receptors (TLRs) are ancient microbial pattern recognition receptors highly
conserved from Drosophila to humans. To investigate if subsets of human dendritic cell …

Understanding how thymic selection imparts self-peptide–MHC complex restriction and a
high degree of self tolerance on the T cell repertoire requires a detailed description of the …

The developmental pathways that lead to the production of antigen-presenting dendritic
cells (DCs) are beginning to be understood. These are the last of the pathways of …

Mouse lymphoid tissues contain a subset of dendritic cells (DCs) expressing CD8α together
with a pattern of other surface molecules that distinguishes them from other DCs. These …