Selected reaction monitoring (SRM) is a targeted mass spectrometry technique that is
emerging in the field of proteomics as a complement to untargeted shotgun methods. SRM is …

Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …

Cancer genomics research aims to advance personalized oncology by finding and targeting
specific genetic alterations associated with cancers. In genome-driven oncology, treatments …

The development of plasma biomarkers has proven to be more challenging than initially
anticipated. Many studies have reported lists of candidate proteins rather than validated …

Inevitable byproducts of aerobic metabolism are free radicals and other highly reactive
oxidants and nitrosants that are continuously formed within cells. Most cells generally …

The rigorous testing of hypotheses on suitable sample cohorts is a major limitation in
translational research. This is particularly the case for the validation of protein biomarkers; …

Proteomics experiments based on Selected Reaction Monitoring (SRM, also referred to as
Multiple Reaction Monitoring or MRM) are being used to target large numbers of protein …

SWATH‐MS is a data‐independent acquisition method that generates, in a single
measurement, a complete recording of the fragment ion spectra of all the analytes in a …

MS‐based proteomics has emerged as a powerful tool in biological studies. The shotgun
proteomics strategy, in which proteolytic peptides are analyzed in data‐dependent mode …

MS-based proteomics generates rapidly increasing amounts of precise and quantitative
information. Analysis of individual proteomic experiments has made great strides, but the …