The human oral cavity is home to an abundant and diverse microbial community (ie, the oral
microbiome), whose composition and roles in health and disease have been the focus of …

The defining feature of the Gram-negative cell envelope is the presence of two cellular
membranes, with the specialized glycolipid lipopolysaccharide (LPS) exclusively found on …

Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of
modern germ theory. Recent studies implicate mucosal surfaces as sites of disease …

Rheumatoid arthritis (RA), an autoimmune disease that affects∼ 1% of the human
population, is driven by autoantibodies that target modified self-epitopes, whereas∼ 11% of …

We carried out metagenomic shotgun sequencing and a metagenome-wide association
study (MGWAS) of fecal, dental and salivary samples from a cohort of individuals with …

Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined
respectively by the destruction of the articular cartilage and tooth‐supporting periodontal …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …

Observations from numerous clinical, epidemiological and serological studies link
periodontitis with severity and progression of rheumatoid arthritis. The strong association is …

Autoimmune diseases are characterized by the body's own immune system attack to the self-
tissues, a condition enabled, in predisposed subjects, by the reduction of self-tolerance. A …